Bone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects
Hyung-Chul Pae , Joo-Hyun Kang, Jae-Kook Cha, Jung-Seok Lee, Jeong-Won Paik, Ui-Won Jung, Seong-Ho Choi
Department of periodontology, Research institute of periodontal regeneration, Yonsei University College of Dentistry, Seoul, South Korea
Received 1 October 2018; revised 21 December 2018; accepted 27 December 2018
Published online 00 Month 2019 in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/jbm.b.34317
Abstract: The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of
the three- dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit
calvarial model. In this work, four circular defects (diameter: 8 mm) in cal- varium of rabbits were randomly assigned to
(1) negative control (control), (2) 3D hexahedron channel structured BCP block,
(3) deproteinized bovine bone mineral particle, and
(4) deprotei- nized porcine bone mineral particle. Animals were euthanized at 2(n=5) and 8 weeks (n=5).
Outcome measures included micro- computed tomography (CT) and histomorphometrical analysis.
Results indicated that in micro-CT, BCP group showed the high- est new bone volume with significant difference compared to
control (p = 0.008) at 8 weeks. Histomorphometrically, total aug- mented area of BCP group was the highest
with significant differ- ence compared to control (p = 0.008) at 8 weeks.
BCP group also maintained total volume of the original defect without collapsing.
BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and
volume maintaining ability and highly porous structure might attribute to new bone formation.
Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed.¨Ï2019 Wiley Periodicals,
Inc. J Biomed Mater Res B Part B: 00B: 000-000, 2019.
Key Words: 3D structure, biphasic calcium phosphate, bone regeneration, synthetic
How to cite this article: Pae H-C, Kang J-H, Cha J-K, Lee J-S, Paik J-W, Jung U-W, Choi S-H. 2019. Bone regeneration using three- dimensional hexahedron channel structured BCP block in rabbit calvarial defects. J Biomed Mater Res B Part B. 2019:9999B:1-9.