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Bone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects
Hyung-Chul Pae , Joo-Hyun Kang, Jae-Kook Cha, Jung-Seok Lee, Jeong-Won Paik, Ui-Won Jung, Seong-Ho Choi

Department of periodontology, Research institute of periodontal regeneration, Yonsei University College of Dentistry, Seoul, South Korea Received 1 October 2018; revised 21 December 2018; accepted 27 December 2018 Published online 00 Month 2019 in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/jbm.b.34317

Abstract: The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three- dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in cal- varium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deprotei- nized porcine bone mineral particle. Animals were euthanized at 2(n=5) and 8 weeks (n=5). Outcome measures included micro- computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro-CT, BCP group showed the high- est new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total aug- mented area of BCP group was the highest with significant differ- ence compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed.ⓒ2019 Wiley Periodicals, Inc. J Biomed Mater Res B Part B: 00B: 000-000, 2019.

Key Words: 3D structure, biphasic calcium phosphate, bone regeneration, synthetic

How to cite this article: Pae H-C, Kang J-H, Cha J-K, Lee J-S, Paik J-W, Jung U-W, Choi S-H. 2019. Bone regeneration using three- dimensional hexahedron channel structured BCP block in rabbit calvarial defects. J Biomed Mater Res B Part B. 2019:9999B:1-9.